Head Development: Craniofacial genetics makes headway
نویسنده
چکیده
Studies of neural crest migration in animal models, and of human syndromes in which craniofacial development is abnormal, are helping us to understand both prenatal and postnatal development of the head.
منابع مشابه
Deletion of OTX2 in neural ectoderm delays anterior pituitary development.
OTX2 is a homeodomain transcription factor that is necessary for normal head development in mouse and man. Heterozygosity for loss-of-function alleles causes an incompletely penetrant, haploinsufficiency disorder. Affected individuals exhibit a spectrum of features that range from developmental defects in eye and/or pituitary development to acephaly. To investigate the mechanism underlying the ...
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* DDS, MSc, PhD. Assistant Professor of Orthodontics. Rehabilitation Hospital of Craniofacial Anomalies, Bauru Dental School, University of São Paulo Bauru/SP, Brazil. ** Master of Orthodontics, São Paulo City University (Unicid), São Paulo/SP, Brazil. *** Head of the Masters Course in Orthodontics of the São Paulo City University, Unicid, São Paulo/SP, Brazil. **** Professor of the Postgraduat...
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The Dumbo rat possesses some characteristics that evoke several human syndromes, such as Treacher-Collins: shortness of the maxillary, zygomatic and mandibular bones, and low position of the ears. Knowing that many homeobox genes are candidates in craniofacial development, we investigated the involvement of the Msx1 and Dlx1 genes in the Dumbo phenotype with the aim of understanding their possi...
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Based on recent advances in experimental embryology and molecular genetics, the morphogenetic program for the vertebrate cranium is summarized and several unanswered classical problems are reviewed. In particular, the presence of mesodermal segmentation in the head, the homology of the trabecular cartilage, and the origin of the dermal skull roof are discussed. The discovery of the neural-crest...
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عنوان ژورنال:
- Current Biology
دوره 5 شماره
صفحات -
تاریخ انتشار 1995